Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2303863 | 0.84 | PIM1 (0.47) | KDM4EHSD17B10ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL2309286 | 0.80 | KDM4E (0.39) | KDM4EHSD17B10ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL3311129 | 0.78 | CHEK1 (0.51) | KDM4EHSD17B10ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL3310173 | 0.69 | JAK2 (0.52) | HRH3KCNH2 | |
| SCHEMBL3307489 | 0.62 | PIM1 (0.50) | KDM4EHSD17B10ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL21327593 | 0.59 | CSF1R (0.74) | KDM4EHTR1ADRD2HTR2AHRH3 | |
| SCHEMBL3461900 | 0.59 | KDM4E (0.55) | KDM4EHSD17B10ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL5493936 | 0.58 | PIK3CD (0.57) | ALDH1A1CYP1A2HTR2AHRH3HRH1 | |
| SCHEMBL9930559 | 0.57 | HRH3 (0.52) | HTTHRH3KCNH2FLT3PARP1 | |
| SCHEMBL5374851 | 0.56 | HTR1A (0.58) | HTR1ADRD2HTR2AHRH3HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105814-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2005-11-10 | — | — | WO | claimed |
| EP-2349260-A1 | JANUS KINASE INHIBITORS FOR TREATMENT OF DRY EYE AND OTHER EYE RELATED DISEASES | Incyte Corporation (US) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010039939-A1 | JANUS KINASE INHIBITORS FOR TREATMENT OF DRY EYE AND OTHER EYE RELATED DISEASES | INCYTE CORPORATION (US) | 2010-04-08 | — | — | WO | disclosed |