Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NME2 | P22392 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2306444 | 0.84 | KDM4E (0.45) | KDM4EHSD17B10ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL2309286 | 0.79 | KDM4E (0.39) | KDM4EHSD17B10ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL3307489 | 0.78 | PIM1 (0.50) | PIM1POLBGAAKDM4EHSD17B10 | |
| SCHEMBL10324538 | 0.66 | PIM1 (1.00) | PIM1POLBGAATSHR | |
| SCHEMBL3314032 | 0.64 | RAB9A (0.42) | PIM1GAAKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL3305580 | 0.63 | JAK2 (0.49) | PIM1POLBKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL3311129 | 0.62 | CHEK1 (0.51) | PIM1KDM4EHSD17B10ALDH1A1HTT | |
| SCHEMBL8243016 | 0.62 | LMNA (0.58) | POLBGAAKDM4EALDH1A1HTT | |
| SCHEMBL18226161 | 0.62 | CHRNA7 (0.48) | PIM1GAAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL24559426 | 0.62 | POLB (1.00) | PIM1POLBGAAHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349260-A1 | JANUS KINASE INHIBITORS FOR TREATMENT OF DRY EYE AND OTHER EYE RELATED DISEASES | Incyte Corporation (US) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010039939-A1 | JANUS KINASE INHIBITORS FOR TREATMENT OF DRY EYE AND OTHER EYE RELATED DISEASES | INCYTE CORPORATION (US) | 2010-04-08 | — | — | WO | disclosed |