Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.42 |
| ▸ | HPGD | P15428 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.42 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.42 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.42 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.42 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28436894 | 1.00 | KDM4E (0.42) | KDM4EHPGDALDH1A1MAPTL3MBTL1 | |
| SCHEMBL23065877 | 1.00 | KDM4E (0.42) | KDM4EHPGDALDH1A1MAPTL3MBTL1 | |
| SCHEMBL23038879 | 0.86 | POLB (0.41) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL23039146 | 0.86 | POLB (0.41) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL23038876 | 0.86 | POLB (0.41) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL2088511 | 0.85 | KDM4E (0.47) | KDM4EHPGDALDH1A1MAPTL3MBTL1 | |
| SCHEMBL23039063 | 0.83 | KDM4E (0.46) | KDM4EHPGDALDH1A1MAPTL3MBTL1 | |
| SCHEMBL20807633 | 0.83 | KDM4E (0.46) | KDM4EHPGDALDH1A1MAPTL3MBTL1 | |
| SCHEMBL23065853 | 0.83 | KDM4E (0.46) | KDM4EHPGDALDH1A1MAPTL3MBTL1 | |
| SCHEMBL23038999 | 0.83 | KDM4E (0.30) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4074708-A1 | 1-(4-(ISOXAZOL-5-YL)-1H-PYRAZOL-1-YL)-2-METHYLPROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS IL-7 AND IFN-GAMMA INHIBITORS FOR TREATING AUTOIMMUNE DISEASES AND CHRONIC INFLAMMATION | Immunic AG (DE) | 2022-10-19 | — | — | EP | disclosed |
| US-11292788-B2 | IL-17 and IFN-gamma inhibition for the treatment of autoimmune diseases and chronic inflammation | IMMUNIC AG (DE) | 2022-04-05 | — | — | US | disclosed |
| US-20210061796-A1 | IL-17 and IFN-gamma inhibition for the treatment of autoimmune diseases and chronic inflammation | IMMUNIC AG (DE) | 2021-03-04 | — | — | US | disclosed |
| CN-111433202-A | 1- (4- (isoxazol-5-yl) -1H-pyrazol-1-yl) -2-methylpropan-2-ol derivatives and related compounds as I L-17 and IFN-gamma inhibitors for the treatment of autoimmune diseases and chronic inflammation | 埃慕尼克股份公司 | 2020-07-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210061796-A1 | IL-17 and IFN-gamma inhibition for the treatment of autoimmune diseases and chronic inflammation | IFNG, IL17A, IFNAR1 | KDM4E 972/4885HPGD 638/4885ALDH1A1 1850/4885 |
| US-11292788-B2 | IL-17 and IFN-gamma inhibition for the treatment of autoimmune diseases and chronic inflammation | IFNG, IL17A, IFNAR1 | KDM4E 972/4885HPGD 638/4885ALDH1A1 1850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.