Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | HTR3A | P46098 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13241649 | 0.81 | SLC6A4 (0.68) | SLC6A4LMNAALDH1A1BLMNPSR1 | |
| SCHEMBL11705626 | 0.79 | SLC6A4 (0.65) | SLC6A4LMNAALDH1A1BLMNPSR1 | |
| SCHEMBL1191221 | 0.77 | SLC6A4 (0.63) | SLC6A4LMNAALDH1A1BLMNPSR1 | |
| SCHEMBL1191610 | 0.77 | SLC6A4 (0.63) | SLC6A4LMNAALDH1A1BLMNPSR1 | |
| SCHEMBL27971821 | 0.75 | CYP2C9 (0.72) | SLC6A4LMNAALDH1A1BLMNPSR1 | |
| SCHEMBL5322962 | 0.74 | MEN1 (0.44) | LMNAALDH1A1CYP2C9CYP1A2HPGD | |
| SCHEMBL7829200 | 0.74 | SLC6A4 (0.59) | SLC6A4LMNAALDH1A1BLMNPSR1 | |
| SCHEMBL18796077 | 0.74 | SLC6A4 (0.59) | SLC6A4ALDH1A1SLC6A2SLC6A3MEN1 | |
| SCHEMBL29686359 | 0.74 | APOBEC3G (0.52) | LMNANPSR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2271692 | 0.74 | HDAC1 (0.57) | SLC6A4LMNAALDH1A1BLMNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349999-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | Universität des Saarlandes (DE) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | disclosed |