Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.38 |
| ▸ | MC4R | P32245 | 6/20 | 0.38 |
| ▸ | MC5R | P33032 | 3/20 | 0.38 |
| ▸ | MC3R | P41968 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | MC1R | Q01726 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4976260 | 0.86 | SLC6A2 (0.35) | CCR2GRIN2BHSD11B1SLC6A2 | |
| SCHEMBL462739 | 0.78 | CCR2 (0.40) | CCR2GRIN2BMC4RMC5RMC3R | |
| SCHEMBL462738 | 0.78 | CCR2 (0.40) | CCR2GRIN2BMC4RMC5RMC3R | |
| SCHEMBL23070668 | 0.71 | JAK2 (0.33) | — | |
| SCHEMBL23070652 | 0.71 | JAK2 (0.33) | — | |
| SCHEMBL18780625 | 0.70 | CCR2 (0.44) | CCR2GRIN2BMC4RMC5RMC3R | |
| SCHEMBL17920816 | 0.69 | PDE4D (0.41) | — | |
| SCHEMBL17353008 | 0.69 | PDE4D (0.41) | — | |
| SCHEMBL28469141 | 0.68 | PSEN1 (0.37) | SLC6A2 | |
| SCHEMBL4067819 | 0.67 | CCR2 (0.38) | CCR2GRIN2BHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2678338-B1 | PYRAZOLO[1,5-A]PYRIDINES AS TRK INHIBITORS | NOVARTIS AG (CH) | 2015-09-09 | — | — | EP | disclosed |