Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NHERF1 | O14745 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 11/20 | 0.46 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | PYGL | P06737 | 2/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2308694 | 1.00 | NHERF1 (0.46) | NHERF1CDK2ITGB1ITGA4PYGL | |
| SCHEMBL2307896 | 0.94 | ITGB1 (0.43) | NHERF1CDK2ITGB1ITGA4PYGL | |
| SCHEMBL2308485 | 0.91 | ITGB1 (0.41) | NHERF1CDK2ITGB1ITGA4PYGL | |
| SCHEMBL2310490 | 0.91 | PYGL (0.47) | ITGB1ITGA4PYGLMEN1KMT2A | |
| SCHEMBL2314270 | 0.91 | PYGL (0.47) | ITGB1ITGA4PYGLMEN1KMT2A | |
| SCHEMBL2308821 | 0.90 | ITGB1 (0.42) | NHERF1CDK2ITGB1ITGA4PYGL | |
| SCHEMBL12386809 | 0.90 | DHODH (0.43) | CDK2ITGB1ITGA4PYGLMEN1 | |
| SCHEMBL2309305 | 0.90 | DHODH (0.43) | CDK2ITGB1ITGA4PYGLMEN1 | |
| SCHEMBL2311936 | 0.90 | ITGB1 (0.41) | NHERF1CDK2ITGB1ITGA4PYGL | |
| SCHEMBL2312066 | 0.89 | ITGB1 (0.44) | NHERF1CDK2ITGB1ITGA4PYGL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288549-B2 | Glycine B antagonist | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-10-16 | — | — | US | disclosed |
| US-20110190342-A1 | GLYCINE B ANTAGONIST | HENRICH MARKUS | 2011-08-04 | — | — | US | disclosed |
| EP-2350014-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010037533-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO KGAA (DE) | 2010-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190342-A1 | GLYCINE B ANTAGONIST | GRIN2B, GLRB, GRIN2A | NHERF1 1336/4885CDK2 1482/4885ITGB1 4760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.