Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.45 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 5/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL484279 | 0.85 | GPR119 (0.53) | GPR119 | |
| SCHEMBL23071022 | 0.84 | GPR119 (0.41) | GPR119SCD5CYP11B2ACACB | |
| SCHEMBL9994892 | 0.83 | GPR119 (0.44) | GPR119SCD5CYP11B2ACACB | |
| SCHEMBL26967191 | 0.82 | GPR119 (0.49) | GPR119SCD5CYP11B2ACACB | |
| SCHEMBL16122895 | 0.82 | CYP11B2 (0.42) | GPR119SCD5CYP11B2ACACB | |
| SCHEMBL15285140 | 0.80 | GPR119 (0.42) | GPR119SCD5CYP11B2ACACB | |
| SCHEMBL21828491 | 0.79 | GPR119 (0.49) | GPR119 | |
| SCHEMBL15885547 | 0.79 | NR1H2 (0.44) | GPR119 | |
| SCHEMBL18922673 | 0.78 | CYP11B2 (0.45) | GPR119SCD5CYP11B2ACACB | |
| SCHEMBL21996917 | 0.77 | GPR119 (0.47) | GPR119ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112442050-B | RET inhibitor, pharmaceutical composition and application thereof | 广东东阳光药业股份有限公司 | 2024-08-09 | — | — | CN | disclosed |
| CN-113527292-A | RET inhibitor, pharmaceutical composition and application thereof | 广东东阳光药业有限公司 | 2021-10-22 | — | — | CN | disclosed |
| WO-2021043209-A1 | RET INHIBITOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF | 广东东阳光药业有限公司 | 2021-03-11 | — | — | WO | disclosed |