Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 5/20 | 0.40 |
| ▸ | JAK1 | P23458 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29222475 | 0.89 | USP2 (0.41) | USP2SMN1; SMN2CTSKMEN1KMT2A | |
| SCHEMBL17830842 | 0.88 | USP2 (0.45) | USP2SMN1; SMN2CTSKMEN1KMT2A | |
| SCHEMBL1476907 | 0.88 | USP2 (0.45) | USP2SMN1; SMN2CTSKMEN1KMT2A | |
| SCHEMBL10529377 | 0.87 | USP2 (0.44) | USP2SMN1; SMN2CTSKMEN1KMT2A | |
| SCHEMBL17176669 | 0.87 | JAK2 (0.44) | USP2SMN1; SMN2CTSKMEN1KMT2A | |
| SCHEMBL23283111 | 0.87 | USP2 (0.44) | USP2SMN1; SMN2CTSKMEN1KMT2A | |
| SCHEMBL20571615 | 0.87 | USP2 (0.44) | USP2SMN1; SMN2CTSKMEN1KMT2A | |
| SCHEMBL25305211 | 0.86 | CTSK (0.42) | USP2SMN1; SMN2CTSKMEN1KMT2A | |
| SCHEMBL16914502 | 0.86 | USP2 (0.41) | USP2SMN1; SMN2CTSKMEN1KMT2A | |
| SCHEMBL2798365 | 0.85 | USP2 (0.43) | USP2SMN1; SMN2CTSKMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114127053-B | Substituted pyrazine compound, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2023-06-13 | — | — | CN | disclosed |
| CN-114127053-A | Substituted pyrazine compound, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2022-03-01 | — | — | CN | disclosed |
| WO-2021043077-A1 | SUBSTITUTED PYRAZINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2021-03-11 | — | — | WO | disclosed |