Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 10/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.37 |
| ▸ | BRD2 | P25440 | 2/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.35 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23073080 | 0.91 | BRD4 (0.47) | BRD4MAPK14MAPK8BRD2BRD3 | |
| SCHEMBL18164465 | 0.86 | BRD4 (0.62) | BRD4MAPK14MAPK8MAPK9MAPK10 | |
| SCHEMBL19927971 | 0.84 | BRD4 (0.64) | BRD4MAPK14CREBBP | |
| SCHEMBL19930720 | 0.82 | BRD4 (0.68) | BRD4MAPK14MAPK8CREBBP | |
| SCHEMBL19931267 | 0.76 | BRD4 (0.74) | BRD4MAPK14MAPK8RPS6KA4MAPK9 | |
| SCHEMBL21916731 | 0.76 | BRD4 (0.56) | BRD4MAPK14MAPK8RPS6KA4MAPK9 | |
| SCHEMBL19931348 | 0.75 | BRD4 (0.79) | BRD4MAPK14MAPK8RPS6KA4MAPK9 | |
| SCHEMBL20159911 | 0.72 | BRD4 (0.43) | BRD4MAPK14BRD2BRD3CREBBP | |
| SCHEMBL20160232 | 0.72 | BRD4 (0.39) | BRD4BRD2BRD3 | |
| SCHEMBL23073191 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283077-B1 | BROMODOMAIN INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2021-03-10 | — | — | EP | disclosed |