Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 17/20 | 0.60 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.52 |
| ▸ | AR | P10275 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23073371 | 0.83 | PARP1 (0.66) | PARP1 | |
| SCHEMBL23064718 | 0.81 | PARP1 (0.69) | PARP1PARP3 | |
| SCHEMBL12955373 | 0.80 | LMNA (0.68) | PARP1LMNAENPP1AR | |
| SCHEMBL14233391 | 0.77 | PARP1 (0.74) | PARP1PARP3 | |
| SCHEMBL23073370 | 0.77 | PARP1 (0.53) | PARP1PARP3 | |
| Hydrochloric Acid SCHEMBL15918641 | 0.77 | PARP1 (0.72) | PARP1PARP3 | |
| Hydrochloric Acid SCHEMBL15918642 | 0.77 | PARP1 (0.61) | PARP1PARP3LMNAAR | |
| SCHEMBL12798164 | 0.77 | LMNA (0.63) | PARP1LMNAENPP1AR | |
| SCHEMBL8163688 | 0.77 | LMNA (0.63) | PARP1LMNAENPP1AR | |
| SCHEMBL4572876 | 0.77 | PARP1 (0.72) | PARP1LMNAENPP1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3925962-A1 | TRICYCLIC INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE | Rakovina Therapeutics Inc. (CA) | 2021-12-22 | — | — | EP | disclosed |
| EP-2714703-B1 | TRICYCLIC INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | NEWGEN THERAPEUTICS INC (US) | 2021-03-10 | — | — | EP | disclosed |