Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.47 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.46 |
| ▸ | ACACB | O00763 | 5/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.45 |
| ▸ | ALPI | P09923 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | XIAP | P98170 | 1/20 | 0.45 |
| ▸ | ACACA | Q13085 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TPH1 | P17752 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2307418 | 1.00 | ITGB3 (0.49) | ITGB3ITGA2BPTPN1KDM4ESLC7A5 | |
| SCHEMBL2310168 | 0.86 | KDM4E (0.51) | ITGB3ITGA2BPTPN1KDM4ESLC7A5 | |
| SCHEMBL2310157 | 0.86 | KDM4E (0.51) | ITGB3ITGA2BPTPN1KDM4ESLC7A5 | |
| SCHEMBL2312907 | 0.85 | ITGB3 (0.49) | ITGB3ITGA2BPTPN1KDM4ESLC7A5 | |
| SCHEMBL2312094 | 0.85 | LTA4H (0.50) | ITGB3ITGA2BPTPN1KDM4ESLC7A5 | |
| SCHEMBL2313852 | 0.85 | ITGB3 (0.49) | ITGB3ITGA2BPTPN1KDM4ESLC7A5 | |
| SCHEMBL2311016 | 0.85 | PCNA (0.49) | ITGB3ITGA2BPTPN1KDM4ESLC7A5 | |
| SCHEMBL2312099 | 0.85 | LTA4H (0.50) | ITGB3ITGA2BPTPN1KDM4ESLC7A5 | |
| SCHEMBL2311021 | 0.85 | PCNA (0.49) | ITGB3ITGA2BPTPN1KDM4ESLC7A5 | |
| SCHEMBL14478230 | 0.83 | SLC7A5 (0.57) | ITGB3ITGA2BPTPN1KDM4ESLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288549-B2 | Glycine B antagonist | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-10-16 | — | — | US | disclosed |
| US-20110190342-A1 | GLYCINE B ANTAGONIST | HENRICH MARKUS | 2011-08-04 | — | — | US | disclosed |
| EP-2350014-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010037533-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO KGAA (DE) | 2010-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190342-A1 | GLYCINE B ANTAGONIST | GRIN2B, GLRB, GRIN2A | ITGB3 4771/4885ITGA2B 4271/4885PTPN1 3936/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.