Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 16/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23085564 | 0.86 | RIPK1 (0.41) | RIPK1MAP3K14 | |
| SCHEMBL23075411 | 0.81 | RIPK1 (0.49) | RIPK1MAP3K14 | |
| SCHEMBL23085448 | 0.78 | RIPK1 (0.57) | RIPK1 | |
| SCHEMBL30832140 | 0.76 | SLC6A4 (0.40) | BACE1 | |
| SCHEMBL25587249 | 0.74 | BACE1 (0.42) | BACE1 | |
| SCHEMBL25585039 | 0.74 | GRM5 (0.38) | — | |
| SCHEMBL23085476 | 0.71 | MAP3K14 (0.47) | RIPK1NPC1RAB9APOLBNR2F2 | |
| SCHEMBL23081597 | 0.71 | NPC1 (0.47) | RIPK1NPC1RAB9APOLBNR2F2 | |
| SCHEMBL25585024 | 0.71 | CYP19A1 (0.49) | MAP3K14 | |
| SCHEMBL23085713 | 0.70 | RIPK1 (0.48) | RIPK1MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021046382-A1 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | RIGEL PHARMACEUTICALS, INC. (US) | 2021-03-11 | — | — | WO | disclosed |
| WO-2021046407-A1 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | RIGEL PHARMACEUTICALS, INC. (US) | 2021-03-11 | — | — | WO | disclosed |