Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.38 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13649888 | 0.89 | PSEN1 (0.53) | HTR7TMEM97SIGMAR1NPC1RAB9A | |
| SCHEMBL10246104 | 0.88 | NPC1 (0.43) | HTR7TMEM97SIGMAR1NPC1RAB9A | |
| SCHEMBL4404580 | 0.87 | PSEN1 (0.46) | HTR7TMEM97SIGMAR1NPC1RAB9A | |
| SCHEMBL2934286 | 0.86 | HTR7 (0.40) | HTR7TMEM97SIGMAR1NPC1RAB9A | |
| SCHEMBL639859 | 0.86 | NPC1 (0.42) | HTR7TMEM97SIGMAR1NPC1RAB9A | |
| SCHEMBL639468 | 0.86 | HTR7 (0.41) | HTR7TMEM97SIGMAR1NPC1RAB9A | |
| SCHEMBL3313366 | 0.85 | CNR2 (0.43) | HTR7TMEM97SIGMAR1NPC1RAB9A | |
| SCHEMBL640463 | 0.85 | RAB9A (0.41) | HTR7TMEM97SIGMAR1NPC1RAB9A | |
| SCHEMBL639832 | 0.85 | CNR2 (0.43) | HTR7TMEM97SIGMAR1NPC1RAB9A | |
| SCHEMBL13368948 | 0.85 | HTR7 (0.41) | HTR7TMEM97SIGMAR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350003-A1 | SUBSTITUTED DISULFONAMIDES AS BRI-MODULATORS | Grünenthal GmbH (DE) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010051977-A1 | SUBSTITUTED DISULFONAMIDES AS BRI-MODULATORS | Grünenthal GmbH (DE) | 2010-05-14 | — | — | WO | disclosed |