Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | HTR3A | P46098 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | GBA1 | P04062 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28525815 | 0.98 | TDP1 (0.39) | TDP1SLC6A2SLC6A4SLC6A3HTR3A | |
| Hydrochloric Acid SCHEMBL28932911 | 0.86 | CHRNB2 (0.40) | TDP1SLC6A2SLC6A4SLC6A3CHRM2 | |
| SCHEMBL3530639 | 0.84 | — | — | |
| SCHEMBL11326725 | 0.84 | TSHR (0.35) | TSHRCHRM2CHRM1CHRM3 | |
| SCHEMBL4029641 | 0.80 | CTSL (0.34) | TSHRCHRM2CHRM1CHRM3 | |
| SCHEMBL3735981 | 0.80 | — | — | |
| SCHEMBL11527918 | 0.79 | TSHR (0.34) | TSHR | |
| SCHEMBL11330057 | 0.78 | CTSL (0.37) | TSHRGBA1 | |
| SCHEMBL24764789 | 0.77 | TSHR (0.34) | TSHR | |
| SCHEMBL16394631 | 0.77 | TDP1 (0.42) | TDP1SLC6A2SLC6A4SLC6A3HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220204479-A1 | PYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR | Wuhan Humanwell Innovative Drug Research and Development Center Limited Company (CN) | 2022-06-30 | — | — | US | disclosed |
| WO-2021043260-A1 | PYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR | 湖北生物医药产业技术研究院有限公司 | 2021-03-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220204479-A1 | PYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR | TYMP, DPYD, TYMS | TDP1 61/4885SLC6A2 524/4885SLC6A4 542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.