Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 4/20 | 0.43 |
| ▸ | GRM5 | P41594 | 3/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 3/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25586411 | 0.90 | GRM5 (0.40) | RIPK1GRM5CYP11B2CYP11B1PRMT5 | |
| SCHEMBL23081632 | 0.86 | CYP11B1 (0.51) | RIPK1GRM5CYP11B2CYP11B1PRMT5 | |
| SCHEMBL23081899 | 0.82 | RIPK1 (0.49) | RIPK1GRM5GABRA1GABRG2GABRB3 | |
| SCHEMBL23081922 | 0.79 | MAP3K14 (0.49) | RIPK1 | |
| SCHEMBL23081600 | 0.78 | RIPK1 (0.49) | RIPK1GRM5GABRA1GABRG2GABRB3 | |
| SCHEMBL25584836 | 0.76 | RIPK1 (0.47) | RIPK1GRM5CYP11B2CYP11B1PRMT5 | |
| SCHEMBL30387134 | 0.76 | RIPK1 (0.47) | RIPK1GRM5CYP11B2CYP11B1PRMT5 | |
| SCHEMBL23081610 | 0.76 | RIPK1 (0.46) | RIPK1GRM5 | |
| SCHEMBL23081635 | 0.76 | RIPK1 (0.51) | RIPK1GRM5CYP11B2CYP11B1GABRA1 | |
| SCHEMBL23009099 | 0.76 | CYP11B1 (0.45) | RIPK1CYP11B2CYP11B1CYP17A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021046437-A1 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | RIGEL PHARMACEUTICALS, INC. (US) | 2021-03-11 | — | — | WO | disclosed |