Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.49 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 3/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25586388 | 0.91 | NPC1 (0.49) | RIPK1NPC1HCRTR1RAB9APOLB | |
| SCHEMBL23900311 | 0.83 | GRM5 (0.51) | RIPK1NPC1HCRTR1RAB9APOLB | |
| SCHEMBL23081600 | 0.83 | RIPK1 (0.49) | RIPK1GRM5GABRA1GABRG2GABRB3 | |
| SCHEMBL23081900 | 0.82 | RIPK1 (0.43) | RIPK1GRM5GABRA1GABRG2GABRB3 | |
| SCHEMBL23081632 | 0.81 | CYP11B1 (0.51) | RIPK1GRM5 | |
| SCHEMBL23081635 | 0.80 | RIPK1 (0.51) | RIPK1GRM5GABRA1GABRG2GABRB3 | |
| SCHEMBL25587259 | 0.76 | NPC1 (0.47) | RIPK1NPC1HCRTR1RAB9APOLB | |
| SCHEMBL23076327 | 0.75 | RIPK1 (0.48) | RIPK1NPC1RAB9AGRM5GABRA1 | |
| SCHEMBL23081922 | 0.74 | MAP3K14 (0.49) | RIPK1 | |
| SCHEMBL23075920 | 0.74 | RIPK1 (0.48) | RIPK1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021046437-A1 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | RIGEL PHARMACEUTICALS, INC. (US) | 2021-03-11 | — | — | WO | disclosed |