Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 17/20 | 0.45 |
| ▸ | NTRK3 | Q16288 | 10/20 | 0.45 |
| ▸ | NTRK2 | Q16620 | 8/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.41 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20371088 | 0.92 | NTRK1 (0.46) | NTRK1NTRK3NTRK2MKNK2PCSK9 | |
| SCHEMBL20359267 | 0.91 | NTRK1 (0.45) | NTRK1NTRK3NTRK2MKNK2PCSK9 | |
| SCHEMBL20359268 | 0.91 | NTRK1 (0.45) | NTRK1NTRK3NTRK2MKNK2PCSK9 | |
| SCHEMBL18376029 | 0.91 | NTRK1 (0.45) | NTRK1NTRK3NTRK2MKNK2PCSK9 | |
| SCHEMBL31250788 | 0.89 | NTRK1 (0.44) | NTRK1NTRK3NTRK2PCSK9 | |
| SCHEMBL21510296 | 0.88 | NTRK1 (0.49) | NTRK1NTRK3NTRK2 | |
| SCHEMBL29088903 | 0.88 | NTRK1 (0.49) | NTRK1NTRK3NTRK2 | |
| SCHEMBL20359954 | 0.88 | NTRK1 (0.43) | NTRK1NTRK3NTRK2MKNK2 | |
| SCHEMBL21815180 | 0.88 | NTRK1 (0.43) | NTRK1NTRK3NTRK2MKNK2 | |
| SCHEMBL16946813 | 0.88 | NTRK1 (0.43) | NTRK1NTRK3NTRK2MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021042890-A1 | HETEROCYCLIC COMPOUND AND APPLICATION THEREOF AS TRK KINASE INHIBITOR | 罗欣药业(上海)有限公司 | 2021-03-11 | — | — | WO | disclosed |