Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.65 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 3/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL2357492 | 0.93 | DGAT1 (0.58) | DGAT1CASP3SENP8SENP7SENP6 | |
| Bicarbonate SCHEMBL2311510 | 0.91 | DGAT1 (0.77) | DGAT1NPC1RAB9AALDH1A1SMN1; SMN2 | |
| Bicarbonate SCHEMBL2309088 | 0.90 | DGAT1 (0.66) | DGAT1NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL12428668 | 0.88 | DGAT1 (0.65) | DGAT1NPC1RAB9AALDH1A1SMN1; SMN2 | |
| Bicarbonate SCHEMBL2309476 | 0.88 | DGAT1 (0.63) | DGAT1NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2308631 | 0.88 | DGAT1 (0.84) | DGAT1CASP3SENP8SENP7SENP6 | |
| SCHEMBL1748252 | 0.88 | DGAT1 (0.84) | DGAT1CASP3SENP8SENP7SENP6 | |
| SCHEMBL2311689 | 0.88 | DGAT1 (0.84) | DGAT1CASP3SENP8SENP7SENP6 | |
| Bicarbonate SCHEMBL2307502 | 0.88 | DGAT1 (0.63) | DGAT1NPC1RAB9AALDH1A1SMN1; SMN2 | |
| Bicarbonate SCHEMBL2311118 | 0.87 | DGAT1 (0.62) | DGAT1NPC1RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633722-B1 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER HEALTHCARE LLC (US) | 2011-08-03 | — | — | EP | claimed |