Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | TRPC3 | Q13507 | 4/20 | 0.41 |
| ▸ | TRPC6 | Q9Y210 | 4/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL2308632 | 0.93 | DGAT1 (0.65) | DGAT1CASP3SENP8SENP7SENP6 | |
| Bicarbonate SCHEMBL2314526 | 0.91 | DGAT1 (0.67) | DGAT1KMT2AKDM4EMAPTHTT | |
| Bicarbonate SCHEMBL2309476 | 0.88 | DGAT1 (0.63) | DGAT1KMT2AKDM4EHTTABL1 | |
| SCHEMBL2305942 | 0.88 | DGAT1 (0.75) | DGAT1CASP3SENP8SENP7SENP6 | |
| Bicarbonate SCHEMBL2312190 | 0.88 | DGAT1 (0.56) | DGAT1KMT2AABL1NPC1ALDH1A1 | |
| Bicarbonate SCHEMBL2307044 | 0.87 | CSF1R (0.44) | DGAT1CASP3SENP8SENP7SENP6 | |
| Bicarbonate SCHEMBL2310705 | 0.86 | DGAT1 (0.65) | DGAT1KDM4EHTTABL1RORC | |
| Bicarbonate SCHEMBL2311510 | 0.85 | DGAT1 (0.77) | DGAT1KMT2AKDM4EMAPTHTT | |
| Bicarbonate SCHEMBL2309088 | 0.85 | DGAT1 (0.66) | DGAT1KMT2AABL1NPC1ALDH1A1 | |
| Bicarbonate SCHEMBL2311036 | 0.84 | DGAT1 (0.62) | DGAT1KMT2AKDM4EHTTABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633722-B1 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER HEALTHCARE LLC (US) | 2011-08-03 | — | — | EP | claimed |