Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 3/20 | 0.45 |
| ▸ | CTSS | P25774 | 3/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
| ▸ | GABRE | P78334 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL2309400 | 0.92 | HDAC6 (0.47) | CTSLCTSSHCRTR1CSF1RDGAT1 | |
| Bicarbonate SCHEMBL2314871 | 0.89 | DGAT1 (0.51) | CTSLCTSSHCRTR1CSF1RDGAT1 | |
| Bicarbonate SCHEMBL2312892 | 0.88 | HDAC6 (0.47) | CSF1RDGAT1HDAC6CHEK2GABRP | |
| Bicarbonate SCHEMBL2309024 | 0.88 | RAB9A (0.43) | CTSLCTSSCSF1RDGAT1HDAC6 | |
| Bicarbonate SCHEMBL2311872 | 0.87 | HDAC6 (0.47) | CSF1RDGAT1HDAC6CHEK2GABRP | |
| SCHEMBL2309763 | 0.86 | DGAT1 (0.54) | CTSLCTSSHCRTR1DGAT1 | |
| SCHEMBL13760251 | 0.86 | DGAT1 (0.54) | CTSLCTSSHCRTR1DGAT1 | |
| SCHEMBL2308693 | 0.86 | DGAT1 (0.54) | CTSLCTSSHCRTR1DGAT1 | |
| SCHEMBL2310956 | 0.86 | DGAT1 (0.54) | CTSLCTSSHCRTR1DGAT1 | |
| Bicarbonate SCHEMBL2310716 | 0.85 | NPC1 (0.53) | CSF1RDGAT1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633722-B1 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER HEALTHCARE LLC (US) | 2011-08-03 | — | — | EP | claimed |