⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3130481 | 0.98 | POLB (0.50) | — | |
| SCHEMBL2779194 | 0.87 | POLB (0.70) | — | |
| SCHEMBL16561742 | 0.87 | POLB (0.70) | — | |
| SCHEMBL20123392 | 0.87 | POLB (0.70) | — | |
| SCHEMBL14941549 | 0.85 | L3MBTL1 (0.62) | — | |
| SCHEMBL15515007 | 0.79 | — | — | |
| SCHEMBL2568389 | 0.79 | — | — | |
| SCHEMBL2566249 | 0.79 | — | — | |
| SCHEMBL24636870 | 0.77 | — | — | |
| SCHEMBL24636872 | 0.76 | POLB (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230293517-A1 | ANTAGONIST COMPOUNDS | JANSSEN PHARMCEUTICA NV (BE) | 2023-09-21 | — | — | US | disclosed |
| US-20220298107-A1 | SUBSTITUTED UREA DIHYDROOROTATE DEHYDROGENASE INHIBITORS | JANSSEN BIOTECH, INC. | 2022-09-22 | — | — | US | disclosed |
| CN-114286813-A | Substituted urea dihydroorotate dehydrogenase inhibitors | 詹森生物科技公司 | 2022-04-05 | — | — | CN | disclosed |
| EP-2350075-A1 | SUBSTITUTED IMIDAZOÝ1,2B¨PYRIDAZINE COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |