Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TOP1 | P11387 | 1/20 | 0.48 |
| ▸ | F10 | P00742 | 3/20 | 0.47 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22632352 | 0.86 | FADS1 (0.50) | POLBNLRP3HDAC8MAPTMEN1 | |
| Clioxanide SCHEMBL29358452 | 0.78 | POLB (1.00) | POLBNLRP3HDAC8HDAC1HDAC6 | |
| Clioxanide SCHEMBL636665 | 0.78 | POLB (1.00) | POLBNLRP3HDAC8HDAC1HDAC6 | |
| SCHEMBL18160306 | 0.73 | HDAC8 (0.68) | POLBHDAC8HDAC1HDAC6MAPT | |
| SCHEMBL2699617 | 0.72 | POLB (0.55) | POLBNLRP3MAPTMEN1RAB9A | |
| SCHEMBL24460276 | 0.72 | P2RX1 (0.77) | POLBMEN1NPC1LMNAHTT | |
| SCHEMBL14459536 | 0.71 | F10 (0.68) | HDAC8HDAC1HDAC6MAPTMEN1 | |
| SCHEMBL14223829 | 0.71 | POLB (0.67) | POLBNLRP3HDAC8MEN1NPC1 | |
| SCHEMBL20413309 | 0.71 | POLB (0.79) | POLBNLRP3MAPTMEN1NPC1 | |
| SCHEMBL3156904 | 0.71 | KDM4E (0.52) | POLBMAPTLMNAHTTTOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3302492-B1 | HALOGENATED SALICYLANILIDES FOR TREATING CLOSTRIDIUM INFECTIONS | UNION THERAPEUTICS AS (DK) | 2021-03-17 | — | — | EP | disclosed |