Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.47 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17560229 | 0.88 | NPSR1 (0.60) | ALDH1A1HPGDNPSR1KMT2AHSD17B10 | |
| SCHEMBL17560155 | 0.76 | NPSR1 (0.57) | ALDH1A1HPGDNPSR1KMT2AHSD17B10 | |
| SCHEMBL25110080 | 0.76 | HSD17B10 (0.67) | ALDH1A1HPGDNPSR1KMT2AHSD17B10 | |
| SCHEMBL17076711 | 0.73 | NPSR1 (0.60) | ALDH1A1HPGDNPSR1KMT2AHSD17B10 | |
| SCHEMBL2828736 | 0.72 | TSHR (0.75) | ALDH1A1HPGDKMT2AHSD17B10TSHR | |
| SCHEMBL12125043 | 0.70 | HSD17B10 (0.66) | ALDH1A1HPGDNPSR1KMT2AHSD17B10 | |
| SCHEMBL25110078 | 0.69 | HSD17B10 (0.61) | ALDH1A1HPGDNPSR1KMT2AHSD17B10 | |
| SCHEMBL20305945 | 0.68 | ALDH1A1 (0.57) | ALDH1A1HPGDNPSR1KMT2AHSD17B10 | |
| SCHEMBL17560163 | 0.68 | NPSR1 (0.56) | ALDH1A1HPGDNPSR1KMT2AHSD17B10 | |
| SCHEMBL23095704 | 0.67 | NPSR1 (0.54) | ALDH1A1HPGDNPSR1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189048-B1 | AMINOINDANE-, AMINOTETRAHYDRONAPHTHALENE- AND AMINOBENZOCYCLOBUTANE-DERIVED PRMT5-INHIBITORS | CTXT PTY LTD (AU) | 2021-03-17 | — | — | EP | disclosed |