Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.60 |
| ▸ | DRD3 | P35462 | 7/20 | 0.60 |
| ▸ | DRD4 | P21917 | 5/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | DRD5 | P21918 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | HTR1E | P28566 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23097779 | 0.89 | DRD2 (0.66) | DRD2DRD3DRD4KCNH2ADRB2 | |
| SCHEMBL23097784 | 0.89 | DRD2 (0.61) | DRD2DRD3DRD4KCNH2SLC6A2 | |
| SCHEMBL10668573 | 0.89 | DRD3 (0.71) | DRD2DRD3DRD4KCNH2HTR1A | |
| SCHEMBL23097644 | 0.88 | DRD2 (0.58) | DRD2DRD3DRD4ADRB2ADRB1 | |
| SCHEMBL23097596 | 0.87 | DRD2 (0.59) | DRD2DRD3DRD4KCNH2SLC6A2 | |
| SCHEMBL23097661 | 0.87 | DRD3 (0.65) | DRD2DRD3DRD4KCNH2SLC6A2 | |
| SCHEMBL23097603 | 0.86 | DRD2 (0.68) | DRD2DRD3DRD4HTR1ASLC6A2 | |
| SCHEMBL23097788 | 0.85 | DRD2 (0.66) | DRD2DRD3DRD4KCNH2HTR1A | |
| SCHEMBL23097605 | 0.83 | DRD2 (0.59) | DRD2DRD3DRD4KCNH2SLC6A2 | |
| SCHEMBL23097749 | 0.83 | DRD2 (0.58) | DRD2DRD3DRD4KCNH2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170334-B1 | NMDA RECEPTOR ANTAGONISTS FOR NEUROPROTECTION | UNIV EMORY (US) | 2021-03-17 | — | — | EP | disclosed |