Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.66 |
| ▸ | HTR2A | P28223 | 5/20 | 0.66 |
| ▸ | DRD2 | P14416 | 5/20 | 0.66 |
| ▸ | DRD3 | P35462 | 4/20 | 0.66 |
| ▸ | HRH1 | P35367 | 3/20 | 0.66 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.66 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.66 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.62 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | HRH2 | P25021 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23097724 | 0.93 | DRD2 (0.57) | HTR1AHTR2ADRD2DRD3HRH1 | |
| SCHEMBL23097759 | 0.90 | MAPT (0.59) | HTR1AHTR2ADRD2DRD3HRH1 | |
| SCHEMBL23097688 | 0.89 | SLC6A2 (0.57) | HTR1AHTR2ADRD2DRD3HRH1 | |
| SCHEMBL2020791 | 0.89 | DRD2 (0.64) | HTR1AHTR2ADRD2DRD3HRH1 | |
| SCHEMBL23097617 | 0.89 | MAPT (0.59) | HTR1AHTR2ADRD2HRH3MAPT | |
| SCHEMBL23097610 | 0.89 | KCNH2 (0.69) | HTR1AHTR2ADRD2DRD3HRH1 | |
| SCHEMBL23097690 | 0.89 | MAPT (0.65) | DRD2MAPTALDH1A1LMNAKMT2A | |
| SCHEMBL23097574 | 0.88 | DRD3 (0.58) | HTR1AHTR2ADRD2DRD3HRH1 | |
| SCHEMBL23097743 | 0.88 | DRD2 (0.62) | HTR1AHTR2ADRD2DRD3HRH1 | |
| SCHEMBL23097577 | 0.87 | HRH3 (0.59) | HTR1AHTR2ADRD2HRH1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170334-B1 | NMDA RECEPTOR ANTAGONISTS FOR NEUROPROTECTION | UNIV EMORY (US) | 2021-03-17 | — | — | EP | disclosed |