Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 9/20 | 0.39 |
| ▸ | FLT3 | P36888 | 8/20 | 0.39 |
| ▸ | KIT | P10721 | 8/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | LCK | P06239 | 2/20 | 0.37 |
| ▸ | FYN | P06241 | 2/20 | 0.37 |
| ▸ | CSF1R | P07333 | 2/20 | 0.37 |
| ▸ | MET | P08581 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | LTK | P29376 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31754870 | 0.85 | DUSP3 (0.41) | KDRFLT3KITAURKBHIF1A | |
| SCHEMBL30422301 | 0.81 | KCNA5 (0.44) | KDRFLT3KITAURKBTSHR | |
| SCHEMBL2310118 | 0.80 | IKBKE (0.43) | KDRFLT3KITAURKBTSHR | |
| Cyclohexane SCHEMBL2440958 | 0.79 | HIF1A (0.38) | KDRFLT3KITAURKBTSHR | |
| SCHEMBL2305834 | 0.74 | HIF1A (0.36) | KDRFLT3KITAURKBTSHR | |
| SCHEMBL18703326 | 0.73 | ELANE (0.39) | IKBKBTSHRMEN1GAAKMT2A | |
| SCHEMBL2308843 | 0.73 | RBP4 (0.35) | KDRFLT3KITAURKBMET | |
| SCHEMBL16646799 | 0.73 | KDR (0.57) | KDRFLT3KITAURKBABL1 | |
| SCHEMBL8404487 | 0.72 | CYP1A2 (0.41) | KDRFLT3KITAURKBABL1 | |
| SCHEMBL2907438 | 0.72 | HIF1A (0.58) | LCKHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350077-A1 | FUSED, SPIROCYCLIC HETEROAROMATIC COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | AstraZeneca AB (SE) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010043893-A1 | FUSED, SPIROCYCLIC HETEROAROMATIC COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | ASTRAZENECA AB (SE) | 2010-04-22 | — | — | WO | disclosed |