Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.64 |
| ▸ | DRD3 | P35462 | 6/20 | 0.64 |
| ▸ | DRD4 | P21917 | 5/20 | 0.64 |
| ▸ | HTR1A | P08908 | 5/20 | 0.64 |
| ▸ | HTR2A | P28223 | 5/20 | 0.64 |
| ▸ | HTR2C | P28335 | 4/20 | 0.64 |
| ▸ | HTR7 | P34969 | 4/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.64 |
| ▸ | MAOA | P21397 | 5/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.58 |
| ▸ | DRD1 | P21728 | 2/20 | 0.58 |
| ▸ | DRD5 | P21918 | 2/20 | 0.58 |
| ▸ | HTR2B | P41595 | 2/20 | 0.58 |
| ▸ | HTR6 | P50406 | 2/20 | 0.58 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | MLNR | O43193 | 1/20 | 0.58 |
| ▸ | HTR3B | O95264 | 1/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23097612 | 0.91 | MAOB (0.57) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL11344730 | 0.90 | KCNH2 (0.69) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL23097691 | 0.88 | DRD2 (0.67) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL23097668 | 0.86 | DRD2 (0.64) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL23097594 | 0.86 | DRD2 (0.64) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL23097664 | 0.86 | DRD2 (0.69) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL23097597 | 0.86 | DRD2 (0.66) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL23097641 | 0.86 | DRD2 (0.66) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL23097720 | 0.86 | DRD2 (0.75) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL10571461 | 0.86 | DRD2 (0.66) | DRD2DRD3DRD4HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170334-B1 | NMDA RECEPTOR ANTAGONISTS FOR NEUROPROTECTION | UNIV EMORY (US) | 2021-03-17 | — | — | EP | disclosed |