Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | RAF1 | P04049 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CES1 | P23141 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3326055 | 0.81 | GNRHR (0.35) | MGLLMAPTNPSR1KDM4ELMNA | |
| SCHEMBL2304261 | 0.81 | IDO1 (0.42) | MGLLMAPTNPSR1KDM4ELMNA | |
| SCHEMBL281336 | 0.75 | CES1 (0.50) | NPSR1ALDH1A1CES2BCHEGAA | |
| SCHEMBL14830556 | 0.72 | NPSR1 (0.56) | MGLLMAPTNPSR1MEN1KMT2A | |
| SCHEMBL15206754 | 0.69 | TTR (0.50) | MGLLMAPTLMNAMEN1KMT2A | |
| SCHEMBL2579627 | 0.69 | ALDH1A1 (0.42) | MAPTNPSR1KDM4ELMNAMEN1 | |
| SCHEMBL2306608 | 0.68 | CHRM1 (0.49) | NPSR1ALDH1A1CES2BCHEGAA | |
| Hexane SCHEMBL28139534 | 0.67 | ALDH1A1 (0.56) | NPSR1ALDH1A1CES2BCHEGAA | |
| SCHEMBL9720982 | 0.67 | KMT2A (0.60) | MAPTNPSR1KDM4ELMNAMEN1 | |
| SCHEMBL2304466 | 0.65 | ALDH1A1 (0.54) | ALDH1A1MAPK1L3MBTL1CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350090-A2 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | Xenon Pharmaceuticals Inc. (CA) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010045251-A2 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS, INC. (CA) | 2010-04-22 | — | — | WO | disclosed |