Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.60 |
| ▸ | GAA | P10253 | 3/20 | 0.60 |
| ▸ | CASP1 | P29466 | 2/20 | 0.60 |
| ▸ | CASP7 | P55210 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | PDE6D | O43924 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | MPI | P34949 | 1/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.47 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9720939 | 0.81 | KMT2A (0.42) | KMT2AKDM4EGAACASP1CASP7 | |
| SCHEMBL27273790 | 0.78 | KMT2A (0.69) | KMT2AKDM4EGAACASP1CASP7 | |
| SCHEMBL25583422 | 0.76 | KDM4E (0.58) | KMT2AKDM4EGAACASP1CASP7 | |
| SCHEMBL281336 | 0.76 | CES1 (0.50) | GAAALDH1A1NPSR1 | |
| SCHEMBL9290287 | 0.75 | PDE6D (0.82) | KMT2AKDM4EGAACASP1HTT | |
| SCHEMBL22247893 | 0.73 | KMT2A (0.67) | KMT2AKDM4EGAACASP1CASP7 | |
| SCHEMBL12643002 | 0.72 | ALDH1A1 (0.55) | KMT2AKDM4EGAACASP1CASP7 | |
| SCHEMBL9921190 | 0.71 | KMT2A (0.59) | KMT2AKDM4EGAACASP1CASP7 | |
| SCHEMBL10869116 | 0.70 | PDE6D (0.81) | KMT2AKDM4EGAACASP1CASP7 | |
| SCHEMBL13143101 | 0.69 | PABPC1 (0.54) | KMT2AKDM4ELMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5079247-A | N1 -substituted benz(cd)indol-2-imine compounds as cardiovascular agents | AMERICAN CYANAMID COMPANY (US) | 1992-01-07 | — | — | US | disclosed |