Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 2/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 3/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1547520 | 0.84 | CES2 (0.41) | RPS6KA3JAK3NFE2L2IDO1TDO2 | |
| SCHEMBL27585754 | 0.79 | TSHR (0.42) | TSHRMAPK1NR2E1KIF11RPS6KA3 | |
| SCHEMBL22572970 | 0.79 | TSHR (0.42) | TSHRMAPK1NR2E1KIF11RPS6KA3 | |
| SCHEMBL394717 | 0.77 | TSHR (0.56) | TSHRMAPK1NR2E1KIF11IDO1 | |
| SCHEMBL130383 | 0.77 | TSHR (0.56) | TSHRMAPK1NR2E1KIF11IDO1 | |
| Hydrochloric Acid SCHEMBL9741395 | 0.74 | TSHR (0.54) | TSHRMAPK1NR2E1KIF11IDO1 | |
| Iodide SCHEMBL31550893 | 0.74 | TSHR (0.54) | TSHRMAPK1NR2E1KIF11IDO1 | |
| SCHEMBL27859051 | 0.74 | TSHR (0.54) | TSHRMAPK1NR2E1KIF11IDO1 | |
| SCHEMBL20569493 | 0.72 | RPS6KA3 (0.40) | TSHRMAPK1NR2E1RPS6KA3JAK3 | |
| SCHEMBL3981283 | 0.71 | CYP19A1 (0.33) | TSHRNFE2L2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2348860-A1 | PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS | Genentech, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |