SCHEMBL2310167

SCHEMBL2310167

[CH2]c1ccccc1-c1ccno1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.46
CYP19A1 P11511 3/20 0.46
CYP2C9 P11712 3/20 0.46
CYP2C19 P33261 3/20 0.46
EPHX2 P34913 1/20 0.41
ADRA1A P35348 3/20 0.40
ADRA1D P25100 2/20 0.40
ADRA1B P35368 2/20 0.40
KDM4E B2RXH2 1/20 0.40
ALDH1A1 P00352 1/20 0.40
GAA P10253 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
NOTUM Q6P988 1/20 0.39
ACLY P53396 1/20 0.34
AR P10275 1/20 0.33
PRMT5 O14744 1/20 0.33
WDR77 Q9BQA1 1/20 0.33
EDNRB P24530 1/20 0.33
EDNRA P25101 1/20 0.33
RAB9A P51151 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29541546 0.77 CYP1A2 (0.47) CYP1A2CYP19A1CYP2C9CYP2C19EPHX2
SCHEMBL6817772 0.77 CYP1A2 (0.47) CYP1A2CYP19A1CYP2C9CYP2C19EPHX2
SCHEMBL7450169 0.75 CYP1A2 (0.46) CYP1A2CYP19A1CYP2C9CYP2C19EPHX2
SCHEMBL29503805 0.75 SMN1; SMN2 (0.51) CYP1A2CYP19A1CYP2C9CYP2C19EPHX2
SCHEMBL6368033 0.75 ALDH1A1 (0.48) CYP1A2CYP19A1CYP2C9CYP2C19EPHX2
SCHEMBL12681544 0.75 SMN1; SMN2 (0.51) CYP1A2CYP19A1CYP2C9CYP2C19EPHX2
SCHEMBL2415309 0.75 EPHX2 (0.58) CYP1A2CYP19A1CYP2C9CYP2C19EPHX2
SCHEMBL2093726 0.75 CYP1A2 (0.58) CYP1A2CYP19A1CYP2C9CYP2C19EPHX2
SCHEMBL927154 0.72 KDM4E (0.45) CYP1A2CYP19A1CYP2C9CYP2C19EPHX2
SCHEMBL12680712 0.72 CYP1A2 (0.47) CYP1A2CYP19A1CYP2C9CYP2C19EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2350090-A2 SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS Xenon Pharmaceuticals Inc. (CA) 2011-08-03 EP disclosed
WO-2010045251-A2 SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS XENON PHARMACEUTICALS, INC. (CA) 2010-04-22 WO disclosed