Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.42 |
| ▸ | SMPD3 | Q9NY59 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23107053 | 1.00 | ABL1 (0.43) | ABL1KMT2AMAPTPIM1PIM3 | |
| SCHEMBL24859477 | 0.92 | ABL1 (0.49) | ABL1MAPTSLC6A9CHRNB2CHRNA4 | |
| SCHEMBL20037743 | 0.92 | ABL1 (0.49) | ABL1MAPTSLC6A9CHRNB2CHRNA4 | |
| SCHEMBL23107766 | 0.91 | MAPT (0.46) | ABL1KMT2AMAPTSMN1; SMN2SLC6A9 | |
| SCHEMBL23107765 | 0.91 | MAPT (0.46) | ABL1KMT2AMAPTSMN1; SMN2SLC6A9 | |
| SCHEMBL14845638 | 0.85 | CHRNB2 (0.45) | ABL1MAPTSLC6A9CHRNB2CHRNA4 | |
| SCHEMBL17664584 | 0.83 | MAPT (0.50) | ABL1MAPTSLC6A9CHRNB2CHRNA4 | |
| SCHEMBL12697233 | 0.83 | NPC1 (0.45) | MAPTCHRNB2CHRNA4CHRNB1CHRNB4 | |
| SCHEMBL25372604 | 0.81 | DOT1L (0.44) | PIM1PIM3PIM2CHRNB2CHRNA4 | |
| SCHEMBL24746250 | 0.81 | SLC6A9 (0.41) | KMT2AMAPTSLC6A9CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021050964-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2021-03-18 | — | — | WO | disclosed |