Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | DRD1 | P21728 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12886549 | 0.82 | CHRNB2 (0.40) | CHRNB2CHRNB4CHRNA3CHRNA4CHRM2 | |
| SCHEMBL12287934 | 0.82 | CHRNB2 (0.40) | CHRNB2CHRNB4CHRNA3CHRNA4CHRM2 | |
| SCHEMBL12886548 | 0.82 | CHRNB2 (0.40) | CHRNB2CHRNB4CHRNA3CHRNA4CHRM2 | |
| SCHEMBL12886557 | 0.79 | CHRNB2 (0.42) | CHRNB2CHRNB4CHRNA3CHRNA4CHRM2 | |
| SCHEMBL12886555 | 0.79 | CHRNB2 (0.42) | CHRNB2CHRNB4CHRNA3CHRNA4CHRM2 | |
| SCHEMBL96929 | 0.79 | CHRNB2 (0.42) | CHRNB2CHRNB4CHRNA3CHRNA4CHRM2 | |
| SCHEMBL19959093 | 0.78 | SMN1; SMN2 (0.43) | CHRNB2CHRNB4CHRNA3CHRNA4CHRM2 | |
| SCHEMBL20711158 | 0.78 | SMN1; SMN2 (0.43) | CHRNB2CHRNB4CHRNA3CHRNA4CHRM2 | |
| SCHEMBL19966241 | 0.78 | NCF1 (0.58) | NCF1CHRM2CHRM1CHRM3MAOA | |
| SCHEMBL1010140 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021050913-A1 | INHIBITORS OF SARM1 | DISARM THERAPEUTICS, INC. (US) | 2021-03-18 | — | — | WO | disclosed |