Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 2/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.47 |
| ▸ | CSGALNACT1 | Q8TDX6 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL2307249 | 0.99 | CASP3 (0.53) | CASP3SENP8SENP7SENP6NPC1 | |
| Bicarbonate SCHEMBL2315409 | 0.98 | CASP3 (0.54) | CASP3SENP8SENP7SENP6NPC1 | |
| Bicarbonate SCHEMBL2310949 | 0.96 | CASP3 (0.58) | CASP3SENP8SENP7SENP6NPC1 | |
| Bicarbonate SCHEMBL2307044 | 0.92 | CSF1R (0.44) | CASP3SENP8SENP7SENP6DGAT1 | |
| SCHEMBL1748162 | 0.91 | DGAT1 (0.51) | CASP3SENP8SENP7SENP6NPC1 | |
| SCHEMBL1748161 | 0.91 | DGAT1 (0.51) | CASP3SENP8SENP7SENP6NPC1 | |
| SCHEMBL1748160 | 0.91 | DGAT1 (0.51) | CASP3SENP8SENP7SENP6NPC1 | |
| Bicarbonate SCHEMBL2306725 | 0.89 | DGAT1 (0.48) | NPC1RAB9AALDH1A1SMN1; SMN2DGAT1 | |
| SCHEMBL1748112 | 0.88 | DGAT1 (0.61) | CASP3SENP8SENP7SENP6NPC1 | |
| SCHEMBL1748111 | 0.88 | DGAT1 (0.61) | CASP3SENP8SENP7SENP6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633722-B1 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER HEALTHCARE LLC (US) | 2011-08-03 | — | — | EP | claimed |