Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23110777 | 0.80 | PTGS2 (0.64) | PTGS2 | |
| SCHEMBL24335035 | 0.79 | PTGS2 (1.00) | PTGS2 | |
| SCHEMBL29443819 | 0.79 | PTGS2 (1.00) | PTGS2 | |
| SCHEMBL23110876 | 0.76 | PTGS2 (0.68) | PTGS2 | |
| SCHEMBL23110602 | 0.76 | PTGS2 (0.63) | PTGS2 | |
| SCHEMBL29802836 | 0.75 | CYP1A2 (0.57) | PTGS2MEN1USP2ALDH1A1CYP1A2 | |
| SCHEMBL23093423 | 0.75 | CYP1A2 (0.57) | PTGS2MEN1USP2ALDH1A1CYP1A2 | |
| SCHEMBL23111036 | 0.75 | PTGS2 (0.59) | PTGS2USP2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL22827966 | 0.74 | PTGS2 (0.79) | PTGS2 | |
| SCHEMBL22827970 | 0.74 | PTGS2 (1.00) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021050700-A1 | CYCLOOXYGENASE-2 INHIBITORS AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2021-03-18 | — | — | WO | disclosed |