Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 5/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.32 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.32 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13437890 | 0.87 | RIPK1 (0.50) | LMNACA12CA1CA2CA3 | |
| SCHEMBL29486304 | 0.87 | RIPK1 (0.50) | LMNACA12CA1CA2CA3 | |
| SCHEMBL14202858 | 0.87 | RIPK1 (0.50) | LMNACA12CA1CA2CA3 | |
| SCHEMBL563778 | 0.82 | LMNA (0.43) | LMNACA12CA1CA2CA3 | |
| SCHEMBL563943 | 0.82 | LMNA (0.43) | LMNACA12CA1CA2CA3 | |
| SCHEMBL564124 | 0.81 | LMNA (0.43) | LMNACA12CA1CA2CA3 | |
| SCHEMBL10239542 | 0.81 | BRD4 (0.50) | LMNACA12CA1CA2CA3 | |
| SCHEMBL564216 | 0.81 | BRD4 (0.50) | LMNACA12CA1CA2CA3 | |
| SCHEMBL15720799 | 0.79 | RIPK1 (0.48) | LMNACA12CA1CA2CA3 | |
| SCHEMBL16061950 | 0.79 | BRD4 (0.54) | LMNACA12CA1CA2CA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3260118-B1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | UNIV JOHNS HOPKINS (US) | 2021-03-24 | — | — | EP | disclosed |