Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11631687 | 0.83 | MAPT (0.41) | KDM4EALDH1A1TSHRMAPK1POLB | |
| SCHEMBL11630509 | 0.75 | CA2 (0.42) | CA2ATMKDM4EALDH1A1PPARG | |
| SCHEMBL11626985 | 0.74 | CA2 (0.41) | CA2ATMKDM4EALDH1A1TSHR | |
| SCHEMBL3558960 | 0.73 | SLC6A2 (0.39) | TSHRSIGMAR1CYP3A4CYP2D6 | |
| SCHEMBL11643025 | 0.73 | TAAR1 (0.42) | KDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11643824 | 0.73 | CYP2D6 (0.37) | ATMKDM4EALDH1A1HSD17B10POLB | |
| SCHEMBL29845495 | 0.68 | KMT2A (0.47) | CA2ATMKDM4EALDH1A1PPARG | |
| SCHEMBL29152363 | 0.68 | KMT2A (0.47) | CA2ATMKDM4EALDH1A1PPARG | |
| SCHEMBL29152366 | 0.68 | KMT2A (0.47) | CA2ATMKDM4EALDH1A1PPARG | |
| SCHEMBL1719491 | 0.67 | CA2 (0.55) | CA2ATMKDM4EALDH1A1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4031216-A | CARDIAC DISEASE, ARRHYTHMIA | KNOLL A.G. CHEMISCHE FABRIKEN (DT) | 1977-06-21 | — | — | US | claimed |
| US-8044069-B2 | Compounds as calcium channel blockers | ABBOTT LABORATORIES (US) | 2011-10-25 | — | — | US | disclosed |
| EP-2350002-A1 | NOVEL COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | Abbott Laboratories (US) | 2011-08-03 | — | — | EP | disclosed |
| US-20100093730-A1 | NOVEL COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | ABBOTT LABORATORIES (US) | 2010-04-15 | — | — | US | disclosed |
| WO-2010039947-A1 | NOVEL COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | ABBOTT LABORATORIES (US) | 2010-04-08 | — | — | WO | disclosed |
| US-4079137-A | FOR TREATMENT OF VASCULAR AND CARDIAC DISEASES | KNOLL A.G. CHEMISCHE FABRIKEN (DT) | 1978-03-14 | — | — | US | disclosed |
| US-4031216-A | CARDIAC DISEASE, ARRHYTHMIA | KNOLL A.G. CHEMISCHE FABRIKEN (DT) | 1977-06-21 | — | — | US | disclosed |
| US-3996360-A | ANTIARRHYTHMIA | KNOLL A.G. CHEMISCHE FABRIKEN (DT) | 1976-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093730-A1 | NOVEL COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | CACNA1E, CACNA1S, CACNA1D | CA2 113/4885ATM 3405/4885KDM4E 3816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.