Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | CD44 | P16070 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22946826 | 0.79 | ALDH1A1 (0.38) | KEAP1NFE2L2MAPTHTTRAPGEF4 | |
| SCHEMBL4037942 | 0.77 | CD44 (0.39) | KEAP1NFE2L2MAPTHTTRAPGEF4 | |
| SCHEMBL21938340 | 0.77 | MAPT (0.37) | KEAP1NFE2L2MAPTHTTRAPGEF4 | |
| SCHEMBL11411291 | 0.77 | CLCN2 (0.39) | KEAP1NFE2L2MAPTHTTNPC1 | |
| SCHEMBL20688029 | 0.77 | ALDH1A1 (0.38) | KEAP1NFE2L2MAPTHTTRAPGEF4 | |
| SCHEMBL10564043 | 0.76 | KEAP1 (0.52) | KEAP1NFE2L2MAPTHTTRAPGEF4 | |
| SCHEMBL262104 | 0.75 | — | — | |
| SCHEMBL144551 | 0.74 | — | — | |
| SCHEMBL21227312 | 0.74 | NR4A2 (0.42) | KEAP1NFE2L2MAPTHTTRAPGEF4 | |
| SCHEMBL31388326 | 0.72 | KMT2A (0.50) | HTTALDH1A1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3793994-A1 | INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE | Biogen MA Inc. (US) | 2021-03-24 | — | — | EP | disclosed |