Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.45 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.44 |
| ▸ | KLK1 | P06870 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1163132 | 0.84 | NPC1 (0.53) | NPC1KDM4EALDH1A1TP53HSP90AA1 | |
| SCHEMBL23128075 | 0.83 | NPC1 (0.51) | NPC1ALDH1A1KDRHDAC6FLT1 | |
| SCHEMBL12939261 | 0.83 | NPC1 (0.46) | NPC1KDM4EALDH1A1TP53HSP90AA1 | |
| SCHEMBL21167740 | 0.81 | NPC1 (0.49) | NPC1KDM4EALDH1A1TP53HSP90AA1 | |
| SCHEMBL21167462 | 0.79 | KDR (0.42) | NPC1ALDH1A1KDRHDAC6HDAC3 | |
| SCHEMBL24591086 | 0.79 | NPC1 (0.47) | NPC1KDM4EALDH1A1TP53HSP90AA1 | |
| SCHEMBL1330149 | 0.79 | NPC1 (0.47) | NPC1KDM4EALDH1A1TP53HSP90AA1 | |
| SCHEMBL21167816 | 0.79 | NPC1 (0.42) | NPC1KDM4EALDH1A1TP53HSP90AA1 | |
| SCHEMBL3395746 | 0.78 | MET (0.48) | NPC1KDM4EALDH1A1TP53HSP90AA1 | |
| SCHEMBL21167629 | 0.78 | NPC1 (0.44) | NPC1KDM4EALDH1A1TP53HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3893872-B1 | ORGANOPHOSPHORUS-SUBSTITUTED COMPOUNDS AS C-MET INHIBITORS AND THERAPEUTIC USES THEREOF | BETA PHARMA INC (US) | 2024-07-17 | — | — | EP | disclosed |
| EP-3795573-A1 | CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRIDINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | Hutchison Medipharma Limited (CN) | 2021-03-24 | — | — | EP | disclosed |