Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 6/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1330149 | 0.84 | NPC1 (0.47) | METNPC1HDAC3CASP6KDM4E | |
| SCHEMBL21167740 | 0.81 | NPC1 (0.49) | METNPC1HDAC3KDM4EALDH1A1 | |
| SCHEMBL3394316 | 0.81 | PIN1 (0.48) | METNPC1HDAC6KDR | |
| SCHEMBL24591086 | 0.79 | NPC1 (0.47) | METNPC1HDAC3KDM4EALDH1A1 | |
| SCHEMBL16012778 | 0.79 | EGFR (0.55) | NPC1CASP6KDM4EALDH1A1TP53 | |
| SCHEMBL23127992 | 0.78 | NPC1 (0.51) | METNPC1HDAC3KDM4EALDH1A1 | |
| SCHEMBL23128076 | 0.78 | NPC1 (0.44) | METNPC1HDAC3KDM4EALDH1A1 | |
| SCHEMBL12069119 | 0.77 | APP (0.55) | ATM | |
| SCHEMBL21167661 | 0.77 | NPC1 (0.45) | METNPC1HDAC3KDM4EALDH1A1 | |
| SCHEMBL1163132 | 0.77 | NPC1 (0.53) | METNPC1HDAC3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247185-B1 | TYROSINE KINASE INHIBITORS | TIGER PHARMATECH (US) | 2014-04-16 | — | — | EP | disclosed |
| EP-2247185-B1 | TYROSINE KINASE INHIBITORS | TIGER PHARMATECH (US) | 2014-04-16 | — | — | EP | disclosed |
| US-8598184-B2 | Protein kinase inhibitors | TIGER PHARMATECH (US) | 2013-12-03 | — | — | US | disclosed |
| US-20100324074-A1 | Protein Kinase Inhibitors | ZHANG JUNHU | 2010-12-23 | — | — | US | disclosed |
| US-20100324074-A1 | Protein Kinase Inhibitors | ZHANG JUNHU | 2010-12-23 | — | — | US | disclosed |
| US-20100324074-A1 | Protein Kinase Inhibitors | ZHANG JUNHU | 2010-12-23 | — | — | US | disclosed |
| EP-2247185-A2 | TYROSINE KINASE INHIBITORS | Tiger Pharmatech (US) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009111354-A2 | TYROSINE KINASE INHIBITORS | TIGER PHARMATECH (US) | 2009-09-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324074-A1 | Protein Kinase Inhibitors | MET, ABL1, ERBB2 | MET 1/4885NPC1 2963/4885HDAC3 3328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.