Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 12/20 | 0.65 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.65 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | STAT1 | P42224 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21831979 | 0.79 | CYP11B2 (1.00) | CYP11B2CYP11B1 | |
| SCHEMBL21831950 | 0.67 | CYP11B2 (0.62) | CYP11B2CYP11B1ABCC8KCNJ11 | |
| SCHEMBL21698783 | 0.63 | POLB (0.37) | CYP11B2KDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL21831980 | 0.61 | CYP11B2 (0.78) | CYP11B2CYP11B1 | |
| SCHEMBL21832048 | 0.61 | CYP11B2 (1.00) | CYP11B2CYP11B1 | |
| SCHEMBL22751731 | 0.60 | CYP11B2 (1.00) | CYP11B2CYP11B1 | |
| SCHEMBL22751729 | 0.59 | CYP11B2 (1.00) | CYP11B2CYP11B1 | |
| SCHEMBL21832043 | 0.59 | CYP11B2 (1.00) | CYP11B2CYP11B1 | |
| SCHEMBL23128959 | 0.59 | CYP11B2 (0.72) | CYP11B2CYP11B1 | |
| SCHEMBL22751735 | 0.59 | CYP11B2 (1.00) | CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3475262-B1 | BICYCLIC IMIDAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF RENAL DISEASE, CARDIOVASCULAR DISEASES AND FIBROTIC DISORDERS | BOEHRINGER INGELHEIM INT (DE) | 2021-03-24 | — | — | EP | disclosed |