Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 2/20 | 0.57 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.42 |
| ▸ | TUBB | P07437 | 2/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.42 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19478673 | 0.95 | PSMB5 (0.52) | PSMB5SKP2TLR8LMNAHIF1A | |
| SCHEMBL7073871 | 0.85 | PSMB5 (0.54) | PSMB5SKP2NPC1RAB9AHPGD | |
| SCHEMBL18805360 | 0.81 | TLR8 (0.51) | TLR8LMNAHIF1ATP53 | |
| SCHEMBL13156563 | 0.81 | TLR8 (0.51) | TLR8LMNAHIF1ATP53 | |
| SCHEMBL19992509 | 0.80 | SMN1; SMN2 (0.46) | NPC1RAB9AHPGDHTTLMNA | |
| SCHEMBL5154662 | 0.79 | TDP1 (0.42) | PSMB5NPC1RAB9ACYP1A2HIF1A | |
| SCHEMBL15127771 | 0.78 | PSMB5 (0.62) | PSMB5SKP2NPC1RAB9AHPGD | |
| SCHEMBL24604651 | 0.76 | TDP1 (0.42) | PSMB5NPC1RAB9ACYP1A2TDP1 | |
| SCHEMBL11455070 | 0.75 | PDE10A (0.57) | PSMB5SKP2NPC1RAB9ATLR8 | |
| SCHEMBL6077149 | 0.75 | PSMB5 (0.48) | PSMB5TLR8LMNAHIF1ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512856-B1 | NOVEL CYTOTOXIC AGENTS AND CONJUGATES THEREOF | POLYTHERICS LTD (GB) | 2021-03-24 | — | — | EP | disclosed |