Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 2/20 | 0.52 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.48 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | TACR2 | P21452 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SHBG | P04278 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23130637 | 0.95 | PSMB5 (0.57) | PSMB5TLR8SKP2LMNATP53 | |
| SCHEMBL18805360 | 0.87 | TLR8 (0.51) | TLR8S1PR4S1PR1S1PR5ESR1 | |
| SCHEMBL13156563 | 0.87 | TLR8 (0.51) | TLR8S1PR4S1PR1S1PR5ESR1 | |
| SCHEMBL7073871 | 0.80 | PSMB5 (0.54) | PSMB5TLR8SKP2KDM4EALDH1A1 | |
| SCHEMBL6077149 | 0.80 | PSMB5 (0.48) | PSMB5TLR8S1PR4S1PR1S1PR5 | |
| SCHEMBL6910786 | 0.79 | TLR8 (0.51) | TLR8S1PR4S1PR1S1PR5SKP2 | |
| SCHEMBL19992509 | 0.79 | SMN1; SMN2 (0.46) | KDM4EALDH1A1LMNATP53CYP3A4 | |
| SCHEMBL5154662 | 0.78 | TDP1 (0.42) | PSMB5KDM4EALDH1A1CYP3A4HIF1A | |
| SCHEMBL12846225 | 0.76 | TLR8 (0.45) | PSMB5TLR8S1PR4S1PR1S1PR5 | |
| SCHEMBL6347222 | 0.75 | ESR1 (0.47) | TLR8ESR1ADRA2AADORA3TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017178828-A1 | CONJUGATES AND CONJUGATING REAGENTS COMPRISING A LINKER THAT INCLUDES AT LEAST TWO (-CH2-CH2-0-) UNITS IN A RING | POLYTHERICS LIMITED (GB) | 2017-10-19 | — | — | WO | disclosed |