Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.57 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.53 |
| ▸ | METAP1 | P53582 | 2/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2308802 | 1.00 | PDE5A (0.57) | PDE5AHSP90AB1METAP1METAP2ADORA3 | |
| SCHEMBL2308803 | 1.00 | PDE5A (0.57) | PDE5AHSP90AB1METAP1METAP2ADORA3 | |
| SCHEMBL12430407 | 0.91 | PDE5A (0.47) | PDE5AHSP90AB1METAP1METAP2ALDH1A1 | |
| SCHEMBL12430434 | 0.91 | PDE5A (0.47) | PDE5AHSP90AB1METAP1METAP2ALDH1A1 | |
| SCHEMBL2309662 | 0.85 | RAB9A (0.55) | ALDH1A1KDM4EPKMHPGDRAB9A | |
| SCHEMBL12431585 | 0.85 | RAB9A (0.55) | ALDH1A1KDM4EPKMHPGDRAB9A | |
| SCHEMBL2309658 | 0.85 | RAB9A (0.55) | ALDH1A1KDM4EPKMHPGDRAB9A | |
| SCHEMBL2312523 | 0.82 | PDE5A (0.60) | PDE5AHSP90AB1METAP1METAP2ADORA3 | |
| SCHEMBL2317808 | 0.80 | CBFB (0.50) | ALDH1A1KDM4EPKMHPGDRAB9A | |
| SCHEMBL3554269 | 0.80 | CDK1 (0.43) | HSP90AB1ALDH1A1KDM4EHPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888579-B1 | NOVEL FLUORENE DERIVATIVES, COMPOSITION CONTAINING SAID DERIVATIVES AND THE USE THEREOF | AVENTIS PHARMA SA (FR) | 2011-08-03 | — | — | EP | claimed |