Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3554267 | 1.00 | CDK1 (0.43) | CDK1CDK2MKNK1MKNK2HSP90AB1 | |
| SCHEMBL2311295 | 0.82 | MEN1 (0.40) | CDK1CDK2MKNK1MKNK2HSP90AB1 | |
| SCHEMBL2311299 | 0.82 | MEN1 (0.40) | CDK1CDK2MKNK1MKNK2HSP90AB1 | |
| SCHEMBL2309662 | 0.82 | RAB9A (0.55) | CDK1CDK2MKNK1MKNK2NPSR1 | |
| SCHEMBL12431585 | 0.82 | RAB9A (0.55) | CDK1CDK2MKNK1MKNK2NPSR1 | |
| SCHEMBL2309658 | 0.82 | RAB9A (0.55) | CDK1CDK2MKNK1MKNK2NPSR1 | |
| SCHEMBL2315903 | 0.80 | CDK1 (0.43) | CDK1CDK2MKNK1MKNK2HSP90AB1 | |
| SCHEMBL2308803 | 0.80 | PDE5A (0.57) | HSP90AB1SMN1; SMN2KDM4EFGFR1FLT1 | |
| SCHEMBL2308802 | 0.80 | PDE5A (0.57) | HSP90AB1SMN1; SMN2KDM4EFGFR1FLT1 | |
| SCHEMBL2313200 | 0.80 | PDE5A (0.57) | HSP90AB1SMN1; SMN2KDM4EFGFR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674795-B2 | Fluorene derivatives, composition containing said derivatives and the use thereof | AVENTIS PHARMA SA (FR) | 2010-03-09 | — | — | US | disclosed |
| US-20080153837-A1 | Novel Fluorene Derivatives, Composition Containing Said Derivatives and the Use Thereof | AVENTIS PHARMA S.A. (FR) | 2008-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153837-A1 | Novel Fluorene Derivatives, Composition Containing Said Derivatives and the Use Thereof | HSP90B1, HSP90AB1, HSP90AA1 | CDK1 2875/4885CDK2 2439/4885MKNK1 550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.