Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | MC4R | P32245 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29992091 | 0.91 | CYP1A2 (0.71) | KDM4EALDH1A1SIGMAR1NPSR1CYP1A2 | |
| SCHEMBL30141847 | 0.91 | CYP1A2 (0.71) | KDM4EALDH1A1SIGMAR1NPSR1CYP1A2 | |
| SCHEMBL1333260 | 0.91 | CYP1A2 (0.71) | KDM4EALDH1A1SIGMAR1NPSR1CYP1A2 | |
| SCHEMBL20804356 | 0.91 | CYP1A2 (0.71) | KDM4EALDH1A1SIGMAR1NPSR1CYP1A2 | |
| SCHEMBL1331974 | 0.91 | CYP1A2 (0.71) | KDM4EALDH1A1SIGMAR1NPSR1CYP1A2 | |
| SCHEMBL28895784 | 0.88 | ALDH1A1 (0.66) | KDM4EALDH1A1SIGMAR1NPSR1CYP1A2 | |
| SCHEMBL8634159 | 0.85 | CYP1A2 (0.65) | KDM4EALDH1A1SIGMAR1NPSR1CYP1A2 | |
| SCHEMBL1822554 | 0.83 | CYP1A2 (0.67) | KDM4EALDH1A1SIGMAR1NPSR1CYP1A2 | |
| SCHEMBL31106560 | 0.83 | CYP1A2 (0.67) | KDM4EALDH1A1SIGMAR1NPSR1CYP1A2 | |
| SCHEMBL15800714 | 0.83 | KDM4E (0.71) | KDM4EALDH1A1NPSR1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893207-B1 | USE OF SUBSTITUTED PIPERAZINE DERIVATIVES AND MORPHOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2011-08-03 | — | — | EP | disclosed |
| EP-1893207-B1 | USE OF SUBSTITUTED PIPERAZINE DERIVATIVES AND MORPHOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2011-08-03 | — | — | EP | disclosed |
| EP-1893207-A1 | USE OF SUBSTITUTED PIPERAZINE DERIVATIVES AND MORPHOLINE DERIVATIVES | Merck Patent GmbH (DE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006133784-A1 | USE OF SUBSTITUTED PIPERAZINE DERIVATIVES AND MORPHOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2006-12-21 | — | — | WO | disclosed |
| US-5753659-A | ANTICOAGULANTS FOR BLOOD DISORDER, CARDIOVASCULAR DISORDER, THROMBOSIS, | ZENECA LIMITED (GB) | 1998-05-19 | — | — | US | disclosed |
| US-5728701-A | INHIBIT PLATELET AGGREGATION | ZENECA LIMITED (GB) | 1998-03-17 | — | — | US | disclosed |