Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 2/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MLNR | O43193 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | HPN | P05981 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.33 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23123669 | 0.93 | CXCR3 (0.35) | DDB1CRBNCXCR3GAAKMT2A | |
| SCHEMBL23121650 | 0.80 | CYP3A4 (0.43) | DDB1CRBNKMT2AMEN1CYP3A4 | |
| SCHEMBL23134742 | 0.80 | DDB1 (0.44) | DDB1CRBNCXCR3GAAALDH1A1 | |
| SCHEMBL23123672 | 0.79 | GAA (0.34) | GAAKMT2AMEN1ALDH1A1MLNR | |
| SCHEMBL30009465 | 0.77 | CYP3A4 (0.40) | KMT2AMEN1CYP3A4 | |
| SCHEMBL23121674 | 0.77 | CYP3A4 (0.40) | KMT2AMEN1CYP3A4 | |
| SCHEMBL23133973 | 0.76 | DDB1 (0.44) | DDB1CRBNALDH1A1 | |
| SCHEMBL23121685 | 0.76 | BRD4 (0.42) | KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL30009142 | 0.75 | CYP3A4 (0.42) | CYP3A4 | |
| SCHEMBL28783614 | 0.74 | DDB1 (0.47) | DDB1CRBNKMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021055295-A1 | BRD9 BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE | NOVARTIS AG (CH) | 2021-03-25 | — | — | WO | disclosed |