Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TET3 | O43151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.32 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.32 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 4/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24497417 | 0.80 | KMT2A (0.40) | TET3KMT2AFBXL19CXXC5TET1 | |
| SCHEMBL21958804 | 0.80 | KMT2A (0.40) | TET3KMT2AFBXL19CXXC5TET1 | |
| SCHEMBL29333077 | 0.79 | KMT2A (0.35) | TET3KMT2AFBXL19CXXC5TET1 | |
| SCHEMBL24595770 | 0.77 | JAK3 (0.40) | TET3KMT2AFBXL19CXXC5TET1 | |
| SCHEMBL25207893 | 0.73 | KMT2A (0.45) | TET3KMT2AFBXL19CXXC5TET1 | |
| SCHEMBL29027503 | 0.72 | CA2 (0.38) | TET3KMT2AFBXL19CXXC5TET1 | |
| SCHEMBL277853 | 0.71 | CA2 (0.48) | TET3KMT2AFBXL19CXXC5TET1 | |
| Hydrochloric Acid SCHEMBL17397450 | 0.69 | CA2 (0.46) | TET3KMT2AFBXL19CXXC5TET1 | |
| SCHEMBL25809391 | 0.69 | L3MBTL3 (0.45) | TET3KMT2AFBXL19CXXC5TET1 | |
| SCHEMBL28238499 | 0.68 | JAK3 (0.31) | JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021055728-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12C MUTANT | MERCK SHARP & DOHME CORP. (US) | 2021-03-25 | — | — | WO | disclosed |