Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2395037 | 0.73 | GSK3B (0.39) | GSK3BHPGDRAB9ANPC1HDAC3 | |
| SCHEMBL180665 | 0.71 | GSK3B (0.53) | GSK3BHPGDRAB9ANPC1HDAC3 | |
| SCHEMBL20142949 | 0.70 | GSK3B (0.52) | GSK3BHPGDRAB9ANPC1HDAC3 | |
| SCHEMBL5006811 | 0.69 | GSK3B (0.43) | GSK3BHPGDRAB9ANPC1HDAC3 | |
| SCHEMBL1748168 | 0.68 | GSK3B (0.46) | GSK3BHPGDRAB9ANPC1HDAC3 | |
| SCHEMBL1748024 | 0.67 | GSK3B (0.48) | GSK3BHPGDRAB9ANPC1HDAC3 | |
| SCHEMBL11430934 | 0.67 | GSK3B (0.57) | GSK3BHPGDRAB9ANPC1HDAC3 | |
| SCHEMBL10021821 | 0.67 | GSK3B (0.57) | GSK3BHPGDRAB9ANPC1HDAC3 | |
| SCHEMBL20530433 | 0.66 | GSK3B (0.50) | GSK3BHPGDRAB9ANPC1HDAC3 | |
| SCHEMBL20159373 | 0.65 | ALDH1A1 (0.50) | GSK3BHPGDRAB9ANPC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633722-B1 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER HEALTHCARE LLC (US) | 2011-08-03 | — | — | EP | disclosed |
| US-7423156-B2 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | BAYER PHARMACEUTICALS CORPORATION (US) | 2008-09-09 | — | — | US | disclosed |