Diphenamide

Diphenamide

SCHEMBL2314459

CN(C)C(=O)C(c1ccccc1)c1ccccc1.COC[C@H](C)N(C(=O)CCl)c1c(C)csc1C

nearest known ligand 0.73

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.73
ALDH1A1 P00352 4/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
LMNA P02545 1/20 0.36
TP53 P04637 1/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
CRHBP P24387 1/20 0.34
CRHR2 Q13324 1/20 0.34
MAPT P10636 1/20 0.33
KDM4E B2RXH2 1/20 0.31
ATM Q13315 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
BRD4 O60885 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dimethenamid SCHEMBL5087814 0.85 THRB (1.00) THRBALDH1A1SMN1; SMN2LMNATP53
Dimethenamid SCHEMBL18223 0.85 THRB (1.00) THRBALDH1A1SMN1; SMN2LMNATP53
Dimethenamid SCHEMBL53864 0.85 THRB (1.00) THRBALDH1A1SMN1; SMN2LMNATP53
Dimethenamid SCHEMBL20723446 0.84 THRB (0.97) THRBALDH1A1SMN1; SMN2LMNATP53
Dimethenamid SCHEMBL20723471 0.84 THRB (0.97) THRBALDH1A1SMN1; SMN2LMNATP53
Dimethenamid SCHEMBL28212854 0.80 THRB (0.88) THRBALDH1A1SMN1; SMN2LMNATP53
Metolachor SCHEMBL17927060 0.79 THRB (0.78) THRBALDH1A1SMN1; SMN2LMNATP53
Dimethenamid SCHEMBL18115317 0.78 THRB (0.72) THRBALDH1A1SMN1; SMN2LMNATP53
Dimethenamid SCHEMBL18115255 0.78 THRB (0.79) THRBALDH1A1SMN1; SMN2LMNATP53
Dimethenamid SCHEMBL14655291 0.76 THRB (0.62) THRBALDH1A1SMN1; SMN2LMNATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011094219-A1 VESICULAR FORMULATIONS KROON HENDRICK-ANDRE (US) 2011-08-04 WO disclosed